Programmed cell death in amyotrophic lateral sclerosis
J. Clin. Invest. Christelle Guégan, et al. 111:153 doi:10.1172/JCI17610 [
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Figure 1Illustrations of PCD alterations in spinal cord of transgenic mutant SOD1 mice. (
a) Photomicrograph of definitely apoptotic cells found in the anterior horn of an end-stage transgenic SOD1
G93A mouse. The arrow shows several typical round chromatin clumps. (
b) Western blot analysis of spinal cord extracts, demonstrating the relocation of Bax from the cytosol (top) to the mitochondria (bottom) over the course of the disease. (
c) Coincidental changes of cytochrome
c in the opposite direction. (
d) Later in the disease, effector caspases such as caspase-7 are activated. 1M (AS): 1 month, asymptomatic stage; 2M (AS): 2 months, asymptomatic stage; 3M (BS): 3 months, beginning of symptoms; 5M (ES): 5 months, end stage; Non-TG: nontransgenic littermates. Modified from ref.
63.
