Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair
J. Clin. Invest. Myriam Alcalay, et al. 112:1751 doi:10.1172/JCI17595 [Go to this article.]

Figure 1
(a) Western blot analysis of fusion-protein expression in the U937 clones used in this study. Asterisks indicate bands corresponding to fusion proteins. The left panel shows PML/RAR levels in the NB4 cell line, which are comparable to those of the U937 PML/RAR and U937 PLZF/RAR cell lines after 8 hours of treatment with 100 μM ZnSO₄. Endogenous RARα expression can be used to compare relative fusion-protein expression levels among different samples. Mt was the control. (b) Venn diagrams representing the overlaps among induced and repressed target genes. PR, PML/RAR; A1E, AML1/ETO; PZR, PLZF/RAR.