Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
J. Clin. Invest. Daniel R. Goldstein, et al. 111:1571 doi:10.1172/JCI17573 [Go to this article.]

Figure 3
Restoration of allograft rejection by provision of either WT donor or recipient APCs. To restore WT recipient or donor APCs, WT females were transplanted with skin from male MyD88^–/– donors (squares) or MyD88^–/– females were transplanted with WT male skin (diamonds). All recipients in both groups consequently rejected their grafts with significantly inferior survival times versus MyD88^–/– recipients of MyD88^–/– male grafts (circles) (P = 0.001 in both cases). However, survival times were significantly longer than those of female MyD88^+/+ recipients of male MyD88^+/+ allografts (triangles) (P = 0.001 vs. MyD88^–/– → MyD88^+/+; P = 0.003 vs. MyD88^+/+ → MyD88^–/–).