An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
J. Clin. Invest. Rembert Koczulla, et al. 111:1665 doi:10.1172/JCI17545 [
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Figure 3Mice with disrupted
Cnlp gene show decreased wound revascularization. (
a and
b) Vascular structures are identified in microsections by CD31 immunostaining at the wound edge 3 days after full-thickness aseptic injury. An asterisk denotes the wound site and location of crust. Wild-type 129/SvJ mice show multiple vascular structures in granulation tissue at the margin of the repairing wound (
a). Mice with homozygous deletion of
Cnlp, therefore lacking CRAMP, have fewer vessels at an identical location relative to the wound (
b). The bar = 12.5 μm in both micrographs. (
c) Numbers of vessels in the skin near the site of injury are significantly decreased in
Cnlp–/– compared with wild-type mice, but are similar distal to the wound in each group (*
P < 0.05;
n = 3/group, three sections per animal).
