An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
J. Clin. Invest. Rembert Koczulla, et al. 111:1665 doi:10.1172/JCI17545 [
Go to this article.]
Figure 2LL-37 induces angiogenesis and arteriogenesis in the rabbit hind-limb model. (
a–
d) Application of the peptide in a rabbit hind-limb model resulted in increased collateral growth in the LL-37–treated animals (
a) as compared with the sLL-37–treated animals (
b) or the buffer control group (
c). bFGF/VEGF was used as positive control (
d). (
e) Collateral growth was significantly increased in the LL-37 group. (
f) Tissue specimens from the calf (gastrocnemius muscle) revealed higher capillary density in the treated group as compared with the control group. (
g) Blood flow velocity as assessed by cinedensitometry of the passage time of the contrast agent between the internal iliac artery and the anterior tibial artery was significantly augmented in the LL-37 group. *
P < 0.05 as compared with the buffer control (
n = 4/group).
