An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
J. Clin. Invest. Rembert Koczulla, et al. 111:1665 doi:10.1172/JCI17545 [Go to this article.]

Figure 1
LL-37 induces physiologic angiogenesis in the CAM assay. (a) LL-37 (5 μg/pellet) induces the formation of wheel spoke–like vessel formation in comparison with the scrambled control peptide sLL-37 or the solvent. bFGF was used as positive control. Bars: 1 mm. (b) Cross sections of CAMs. LL-37 increases the number of erythrocyte-filled vessels (Masson-Goldner stain of erythrocyte-filled vessels). Bars: 250 μm or 62 μm in the ×10 and ×40 micrographs, respectively. (c) The numbers of erythrocyte-filled vessels were counted in hot spots. *P < 0.05 as compared with the solvent group (n = 6/group; three sections per CAM).