Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
J. Clin. Invest. Ventzislav Petkov, et al. 111:1339 doi:10.1172/JCI17500 [
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Figure 3VIP expression in lung tissue. (
a) The immunohistochemical staining of VIP in nerve fibers that were found within media and media-adventitia junctions in pulmonary resistance vessels of healthy (normal) controls. (
b) In contrast, PPH patients show a thickened vessel wall and plexiform lesions without any specific VIP staining (scale bar = 20 μm). Arrows indicate VIP immunoreactive fibers.
