Heterologous immunity provides a potent barrier to transplantation tolerance
J. Clin. Invest. Andrew B. Adams, et al. 111:1887 doi:10.1172/JCI17477 [Go to this article.]

Figure 1
Analysis of viral- and allo-specific responses in vivo. B6 mice were infected with either LCMV, VV, or VSV. The results are displayed for the peak of the response as well as during the memory phase (more than 6 weeks). For comparison, the response to a skin allograft is also shown. (a) Representative dot plots displaying the number of CD8⁺ IFN-γ⁺ T cells representing the antiviral response (LCMV-NP396-404, VV-infected stimulators, VSV-N-peptide; left panels) and the corresponding heterologous allo-specific responses (right panels). (b) The number of virus-specific (NP396-404, filled squares) and virally induced, alloreactive T cells (H-2^d stimulated, filled triangles) after LCMV infection are shown over time. The allo-specific response after skin graft is shown for comparison (H-2^d stimulated, open squares; CD8⁺, upper panel; CD4⁺, lower panel). Each time point represents the average for three animals. Experiments were repeated three times with similar results.