Mature CD8⁺ T lymphocyte response to viral infection during fetal life
J. Clin. Invest. Arnaud Marchant, et al. 111:1747 doi:10.1172/JCI17470 [Go to this article.]

Figure 5
Phenotype of HCMV-specific CD8⁺ T cells in a fetus and an adult with acute HCMV infection. Expression of markers of (a) activation (Ki67, Bcl-2, CD38, HLA-DR), (b) differentiation (CD45RA, CD45RO, CD28, CD27), and (c) cytolytic activity (perforin, granzyme A) by HCMV-specific CD8⁺ T cells from a 28-week-old fetus and from a pregnant women (adult) with acute HCMV infection. Three levels of HLA-DR and perforin expression are shown: negative (neg), low, and high. HCMV-specific CD8⁺ T cells from the fetus had an intermediate differentiation phenotype.