Mature CD8⁺ T lymphocyte response to viral infection during fetal life
J. Clin. Invest. Arnaud Marchant, et al. 111:1747 doi:10.1172/JCI17470 [Go to this article.]

Figure 3
Phenotype of HCMV-specific CD8⁺ T cells from HCMV-infected newborns and immune adults. Expression of markers of activation (Ki67, Bcl-2, CD38, HLA-DR, CD62-L, CD95) and differentiation (CD45RA, CD45RO, CD28, CD27) by HCMV-specific CD8⁺ T cells (gated using the relevant tetramers) of case no. 2 and a representative adult. Three levels of HLA-DR expression are shown: negative, low, and high. HCMV-specific CD8⁺ T cells from infected newborns had a late differentiation phenotype similar to that of adults. Similar results were obtained in cases no. 1, 3, and 4, and in four other immune adults.