Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation
J. Clin. Invest. Mara Chavolla-Calderón, et al. 111:973 doi:10.1172/JCI17458 [
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Figure 5Protection conferred by reconstitution of WT mice with
PPT-A gene–deleted (
PPT-A–/–) bone marrow and by capsaicin-selective denervation against inflammation (neutrophil counts in bronchoalveolar fluid;
P = 0.0005) and increased alveolar-capillary permeability (Evans blue lavage fluid/serum ratio;
P = 0.0014) 24 hours after a 4-hour period of high-volume ventilation. These results demonstrate, in a manner similar to that shown for immune complex–mediated inflammation (see Figure
3), that
PPT-A gene expression by hemopoietic cells is critical for the progression of stretch-mediated inflammation. Values are shown as mean ± SE (
n = 5 for WT-to-WT reconstitution and 4 for all other groups).
