Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
J. Clin. Invest. Tatsuya Kondo, et al. 111:1835 doi:10.1172/JCI17455 [Go to this article.]

Figure 4
The eNOS immunoreactivity in control retina is increased under hypoxia, but is less in VENIFARKO and even less in VENIRKO mice. The eNOS protein was expressed in each control (a and e), VENIRKO (b), and VENIFARKO (f) retina and was strongly increased when exposed to relative hypoxic conditions in the microvascular preretinal area in each control (c and g). The induction of eNOS in VENIRKO retina (d) was decreased 43% (P < 0.01; see Figure 6c), and that in VENIFARKO retina (h) was reduced 31% (P < 0.05; see Figure 6c).