Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
J. Clin. Invest. Tatsuya Kondo, et al. 111:1835 doi:10.1172/JCI17455 [Go to this article.]

Figure 3
VEGF immunoreactivity in control retina is induced under hypoxia, but is less in VENIFARKO and even less in VENIRKO mice. VEGF immunoreactivity was constitutively observed in each control (a and e), VENIRKO (b), and VENIFARKO (f) retina and was highly induced in the ΔO₂ model of each control in the preretinal area (c and g). The induction of VEGF in VENIRKO retina (d) was blunted 34% (P < 0.01; see Figure 6b), and that in VENIFARKO retina (h) was reduced 18% (not significant; see Figure 6b).