Auricular chondritis in NOD.DQ8.Aβo (A^g7–/–) transgenic mice resembles human relapsing polychondritis
J. Clin. Invest. Veena Taneja, et al. 112:1843 doi:10.1172/JCI17450 [Go to this article.]

Figure 7
(a) Cell surface markers on splenic cells as determined by FACS after labeling them with specific mAb’s in B10.DQ8 mice (broken line) and NOD.DQ8 mice (solid line). NOD.DQ8 mice had a lower number of CD8⁺CD25^hi, CD152⁺CD4⁺CD25⁺, and a higher number of B220⁺CD25⁺ cells than B10.DQ8 mice. The data shown were obtained from spleen cells pooled from two mice per strain and represent at least two separate assays. (b) NOD.DQ8 mice produce high levels of TGF-β. Cytokines produced by splenic cells isolated from primed mice and cultured in vitro in the presence of CII and (c) CIX. For each experiment, cells were pooled from two mice per strain.