WNK kinases regulate thiazide-sensitive Na-Cl cotransport
J. Clin. Invest. Chao-Ling Yang, et al. 111:1039 doi:10.1172/JCI17443 [Go to this article.]

Figure 3
Effect of mutant WNK4 on NCC-mediated ²²Na uptake, expressed as nmol/h per oocyte. This figure compares rates of Na uptake (± SEM) of oocytes injected with cRNA encoding NCC and NCC + wild-type WNK4, E559K WNK4, D561A WNK4, and Q562E WNK4. Both wild-type and mutant WNK4 inhibited NCC activity (*P < 0.05 compared with NCC); Q562E reduced uptake significantly less than did wild-type WNK4 (^#P < 0.05 compared with NCC+ WNK4). There were six experiments (15–30 oocytes per experiment).