Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease
J. Clin. Invest. Vanda A. Lennon, et al. 111:907 doi:10.1172/JCI17429 [Go to this article.]

Figure 4
(a–d) Responses of inferior mesenteric ganglion neurons to preganglionic and direct electrical stimulation. (a) Action potential response to single supramaximal stimulus of lumbar colonic nerve in a neuron from a control rabbit (120 V for 1 ms, indicated by an asterisk) and subsequently on direct neuronal depolarization (0.15 nA for 50 ms, indicated by arrows). (b) In a ganglion neuron from a rabbit with severe EAAN, a single supramaximal stimulus to the lumbar colonic nerve (150 V for 1 ms, indicated by an asterisk) does not elicit any response, but direct neuronal depolarization (as in a) elicits an action potential. (c and d) Supramaximal stimulation of lumbar colonic nerves (100 V for 0.5 ms and 120 V for 0.5 ms, respectively) applied once (asterisks) or repetitively at increasing rates elicited repetitive action potential responses from the ganglion neuron of a control rabbit (c) and a rabbit with relatively mild EAAN (d). Synaptic transmission failed more frequently and at lower rates of stimulation in neurons from rabbits with EAAN.