Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis
J. Clin. Invest. Kelly S. Doran, et al. 112:736 doi:10.1172/JCI17335 [Go to this article.]

Figure 4
Transmigration of neutrophils in response to bacterial infection (a) and supernatants of GBS-infected HBMEC (b). In duplicate experiments, neutrophils migrated in response to GBS-induced gene products by the WT or β-h/c–deficient strain with or without 10 μg/ml anti–IL-8, anti–ICAM-1, or IgG1 isotype control antibody. Migration index is the ratio of cells that migrated during an infection or in response to a supernatant (S/N) in comparison with migration across an uninfected monolayer. Error bars represent the 95% confidence interval of the mean of three wells. *P < 0.05 compared with WT. ** P < 0.001 compared with WT or the β-h/c mutant.