Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis
J. Clin. Invest. Kelly S. Doran, et al. 112:736 doi:10.1172/JCI17335 [
Go to this article.]
Figure 3Stimulation of IL-8 release by HBMEC with supernatant (S/N) containing GBS β-h/c activity. Cell culture supernatants were assayed 4 hours after incubation with WT GBS, stabilized supernatant (∼25 U) from WT (β-h/c
+) GBS, and stabilized supernatant from β-h/c mutant (β-h/c
–) GBS. Representative data from duplicate experiments are shown. Error bars represent the 95% confidence interval of the mean of four wells. *
P < 0.001 compared with control. **
P < 0.0001 compared with WT.
