Inducible costimulator is essential for collagen-induced arthritis
J. Clin. Invest. Roza I. Nurieva, et al. 111:701 doi:10.1172/JCI17321 [Go to this article.]

Figure 5
ICOS regulates IL-17 but not CD40L expression. (a) Naive Th cells from ICOS^+/+ mice were stimulated with the indicated combination of anti-CD3, anti-CD28, and anti-ICOS Ab’s. After 4 days, the amounts of Th cytokines (IFN-γ and IL-17) were measured by ELISA. (b) Lymph node cells from ICOS^+/+ and ICOS^–/– mice were activated with αCD3 for 6 hours, stained with mAb to CD40L plus streptavidin-phycoerythrin, and analyzed by flow cytometry (open curves). Control staining is shown as dark curves. The data represent one of two independent experiments with the same results.