Inducible costimulator is essential for collagen-induced arthritis
J. Clin. Invest. Roza I. Nurieva, et al. 111:701 doi:10.1172/JCI17321 [Go to this article.]

Figure 2
Representative hematoxylin and eosin–stained sections of intraphalangeal joints from ICOS^+/+ and ICOS^–/– mice. (a) ICOS^+/+. Notice the even and clear joint space (js) and smooth articular cartilage (ac). Original magnification ×200. (b–f) ICOS^–/–. (b) Notice the fibrovascular synovial and periarticular proliferation (fp) erosion of articular cartilage (ac) intra-articular exudates (ie) and osteolysis in severely affected joints (d). Original magnification ×200. (c) Original magnification ×100. (d) Articular bone remnants (br) from a severely affected mouse. Original magnification ×100. (e) Intra-articular exudates composed of neutrophils (n), other inflammatory cells, and hyperplastic synoviocytes (s) admixed within cellular debris. Original magnification ×400. (f) High magnification of the fibrovascular proliferative tissues composed of primarily hyperplastic fibrocytes (hf), neovascularization (v), and inflammatory cells (ic). Original magnification ×600.