Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
J. Clin. Invest. Julian C. Braz, et al. 111:1475 doi:10.1172/JCI17295 [
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Figure 4dnp38α, dnMKK3, and dnMKK6 transgenic mice have enhanced hypertrophy in response to PE, Ang II, and ISO infusion. Nontransgenic mice or the three transgenic lines were infused with PE, Ang II, or ISO for 14 days with osmotic minipumps, after which the hearts were collected and weighed. The number of mice used in each group is denoted in the graph (*
P < 0.05 versus nontransgenic vehicle;
†P < 0.05 versus dnp38α, dnMKK3, or dnMKK6 vehicle, respectively).
