β-Arrestin-2 regulates the development of allergic asthma
J. Clin. Invest. Julia K.L. Walker, et al. 112:566 doi:10.1172/JCI17265 [
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Figure 7Effect of LPS treatment on airway responsiveness and inflammation. (
a) Effect of genotype and LPS treatment on lung inflammation assessed by identification of cells harvested from whole-lung lavage. Black bars represent WT LPS-treated mice; white bars represent
βarr2–/– LPS-treated mice. Data are mean ± SEM;
n = 13–15 mice per group. (
b) Airway responsiveness to methacholine, defined by the time-integrated change in peak airway pressure was measured for
βarr2–/– (circles) and WT (squares) mice treated with LPS (open symbols) or untreated (filled symbols). Data are mean ± SEM;
n = 13–15 mice per group. *LPS treatment caused a similar significant increase in APTI in WT and
βarr2–/– mice.
P < 0.05.
