Rheumatic fever–associated Streptococcus pyogenes isolates aggregate collagen
J. Clin. Invest. Katrin Dinkla, et al. 111:1905 doi:10.1172/JCI17247 [
Go to this article.]
Figure 6CIV-specific serum responses. (
a) Serum Ig response in M3 protein–immunized mice. Reactivity was determined for preimmune serum pool (PI), serum pool of PBS-immunized (PBS) or M3 protein–immunized (M3) mice, and M3 serum pool after absorbing M3-reactive antibodies (M3-absorbed). (
b) CIV-specific serum responses in patients and controls. Sera were from healthy controls (H,
n = 27), pharyngitis patients (P,
n = 9), or ARF patients (ARF,
n = 5). Antigens were streptolysin O (SLO), GAS polysaccharide (GAS), human heart myosin (MYO), and CIV. Bars represent mean IgG titers of three experiments ± SD. (
c) Anticollagen titer of individual patient sera. Titers are shown for each individual serum collected from ARF patients (triangles), pharyngitis patients (squares), or healthy individuals (circles).
