Rheumatic fever–associated Streptococcus pyogenes isolates aggregate collagen
J. Clin. Invest. Katrin Dinkla, et al. 111:1905 doi:10.1172/JCI17247 [
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Figure 4Capsule expression and collagen-binding activity of a mouse-passaged serotype M1
S. pyogenes. Transmission electron microscopic images show M1
S. pyogenes strain KTL3 grown directly in medium (
a) or cultivated from blood of infected mice (
b). (
c) A highly encapsulated mouse-passaged M18 strain 87282. (
d) Collagen-binding activities are shown for M18 and M1 isolates grown in medium (light gray bars) or cultivated from blood of infected mice (dark gray bars). Collagen binding is expressed as a ratio of bound radiolabeled CIV to streptococci. Bars, 0.25 μm (
a–
c).
