Rheumatic fever–associated Streptococcus pyogenes isolates aggregate collagen
J. Clin. Invest. Katrin Dinkla, et al. 111:1905 doi:10.1172/JCI17247 [
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Figure 1Collagen matrix association of GAS. FESEM shows a thick CIV network on the surface of a collagen-binding M3 strain 86764 (
18) isolated from a rheumatic fever patient (
a) that is absent in strains that do not bind CIV (A40;
b). Transmission electron microscopy of collagen-binding serotype M3 GAS 86764 shows collagen deposition on the surface using immunogold labeling (
c, arrowheads). Asterisks indicate aggregated CIV on the streptococcal surface. Bars, 1 μm (
a and
b) and 0.25 μm (
c).
