A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice
J. Clin. Invest. Natalie A. Sims, et al. 111:1319 doi:10.1172/JCI17246 [
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Figure 4Estradiol treatment of female ERαβ
–/– mice does not significantly alter trabecular bone mass or bone turnover. Intact ERαβ
–/– females were implanted with slow-release pellets delivering estradiol at 30 μg/kg/d. Tb.BMD and BV/TV were not increased by high-dose estradiol treatment. No markers of bone turnover were significantly altered. Shown here are ObS/BS, BFR/BS, and OcS/BS. Values are mean ± SEM.
