Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
J. Clin. Invest. Nathan R. Martinez, et al. 111:1365 doi:10.1172/JCI17166 [
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Figure 5Disabling the B25–C34 CTL epitope permits diabetes prevention by proinsulin peptide. A single intranasal dose of mouse proinsulin B24–C36 (diamonds), B24–C33 (inverted triangles), or B24–C32 (triangles) peptide, or PBS carrier only (squares), was given to 8-week-old female NOD mice (
n = 12 per group). The experiment was terminated at 26 weeks of age, when the majority of control mice had become diabetic.
