Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
J. Clin. Invest. Masaya Kobayashi, et al. 111:1297 doi:10.1172/JCI17085 [Go to this article.]

Figure 1
IBDs in Stat1/Stat3 double-deficient mice. (a-d) Histologic examination of the colons of (a) control, (b) Stat1-deficient, (c) Stat3 mutant, and (d) Stat1/Stat3 double-mutant mice at 8 weeks. H&E staining is shown. ×20. (e)The colitis scores shown for individual mice at 16 weeks of age were total scores for individual sections as described in Methods. The severity of colitis in Stat1/Stat3 double-mutant mice was significantly but only partially improved compared with Stat3 mutant mice (**P < 0.01). *P < 0.001 versus group of control mice.