The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim
J. Clin. Invest. Chun-Rong Chen, et al. 111:1897 doi:10.1172/JCI17069 [Go to this article.]

Figure 5
Comparable high levels of TBI immunoglobulins are induced in mice immunized with adenovirus expressing different structural forms of the TSHR. BALB/c mice were injected intramuscularly with adenovirus expressing the shed A subunit (TSHR-289), the noncleaving receptor (TSHR-D1NET), the WT receptor (TSHR-WT), and control adenovirus (Con). TBI values in mice euthanized after the third adenovirus injection are shown for individual animals; the number of mice in each group is shown in parentheses. There were no statistically significant differences in TBI values between the groups of mice immunized with the different TSHR adenovirus constructs.