The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim
J. Clin. Invest. Chun-Rong Chen, et al. 111:1897 doi:10.1172/JCI17069 [
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Figure 2Serum T4 in mice immunized with adenovirus expressing different structural forms of the TSHR. BALB/c mice were immunized with adenovirus expressing the shed A subunit (TSHR-289) and the noncleaving receptor (TSHR-D1NET). As controls, mice were also injected with adenovirus expressing the WT TSHR (TSHR-WT) or β-gal (Con). Data shown are the individual values for mice in each group (number shown in parentheses). The shaded area indicates the mean ± 2 SD of values for 15 control adenovirus-immunized mice. Serum T4 levels were measured in mice after two adenovirus injections (
a and
b) and at euthanasia after the third adenovirus injections (
c and
d). Immunization with TSHR-289 adenovirus increased serum T4 levels in more mice than immunization with TSHR-D1NET adenovirus. *
P = 0.005; **
P = 0.002; ***
P < 0.001 (Fisher exact test).
