Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A
J. Clin. Invest. Rita Holtwick, et al. 111:1399 doi:10.1172/JCI17061 [Go to this article.]

Figure 8
(a) TAC led to a substantial increase in systolic blood pressure (SBP) proximal to the stenosis. SBP was significantly lower in the CM GC-A KO than in the floxed GC-A mice. For reference, pressures in sham-operated mice averaged 100 ± 6 mmHg (floxed GC-A) and 93 ± 10 mmHg (CM GC-A KO), indicating that a substantial pressure load was induced by TAC in both genotypes. (b) Despite the lower SBP, the CM GC-A KO mice had an increased LVW/BW index compared with the floxed GC-A mice. (c) The linear regression of SBP and LVW/BW index revealed that in the CM GC-A KO mice (filled circles and solid line), a stronger hypertrophic response in the heart correlated with lower blood pressures, while in the floxed GC-A mice (open circles and dashed line), blood pressure and LVW/BW index were positively correlated. (d) To compare the hypertrophic response independently of the differences in blood pressure in this figure, we divided the LVW/BW index of each animal by the individual SBP and normalized this value to the mean SBP of 145 mmHg (n = 18 floxed GC-A and 27 CM GC-A KO mice, *P < 0.05 vs. floxed GC-A).