Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A
J. Clin. Invest. Rita Holtwick, et al. 111:1399 doi:10.1172/JCI17061 [
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Figure 7In vivo hemodynamic measurements of cardiac function by left ventricular catheterization. Heart rate (
a), peak left ventricular systolic pressure (LVSP) (
b), and the maximal rates of contraction (dP/dt
max) (
c) and relaxation (dP/dt
min) (
d) are shown at baseline (0) and during infusion of dobutamine in
CM GC-A KO and
floxed GC-A mice (
n = 6, *
P < 0.05 vs.
floxed GC-A).
