Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
J. Clin. Invest. Qisheng Tu, et al. 111:1029 doi:10.1172/JCI17054 [Go to this article.]

Figure 1
Survival of CasR- and Gcm2-deficient mice. The survival rate of group I, which combines data from heterozygous Gcm2^+/– and wild-type mice (n = 38), was 100%, whereas no group II homozygous CasR-deficient mice (n = 29) survived beyond 3 weeks. Group III homozygous Gcm2-deficient mice (n = 13) had a survival rate of 69%. The survival rates of group IV double homozygous CasR- and Gcm2-deficient mice (71%, n = 14) and group VI mixed heterozygous CasR- and homozygous Gcm2-deficient mice (74%, n = 23) are not different from that of group III Gcm2^–/– mice. Group V, which combines heterozygous CasR^+/– mice and the double heterozygous Gcm2^+/–/CasR^+/– mice (n = 69), had a survival rate of 97%.