Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
J. Clin. Invest. Susan B. Gurley, et al. 116:2218 doi:10.1172/JCI16980 [Go to this article.]

Figure 4
Radiotelemetry measurement of systolic blood pressure before and during Ang II infusion. Systolic blood pressures (SBPs) were recorded continuously in WT (open circles) and ACE2 KO (filled circles) mice. Ang II infusion was initiated on day 1. Baseline SBPs were similar in both groups (day 0). Chronic infusion of Ang II caused blood pressures to increase in both groups. However, by day 4 of Ang II infusion, blood pressure was significantly higher in ACE2 KO mice than in controls and remained higher throughout the remainder of the infusion period (*P < 0.05).