Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance
J. Clin. Invest. Isabelle Rubera, et al. 112:554 doi:10.1172/JCI16956 [Go to this article.]

Figure 6
CCD profiles of kidneys from Scnn1a^loxlox and Scnn1a^loxloxCre mice kept on a sodium-free diet for 6 days. Immunofluorescence on consecutive cryosections with rabbit antibodies against α, β, and γENaC. CCD cells of an Scnn1a^loxlox mouse show a weak but distinct apical immunostaining for α, β, and γENaC. Note the absence of αENaC immunostaining and the diffuse granular cytoplasmic localization of β and γENaC immunostaining in CCD cells of the Scnn1a^loxloxCre mouse. Unstained cells in the CCD profiles are intercalated cells. Scale bar, 20 μm.