Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance
J. Clin. Invest. Isabelle Rubera, et al. 112:554 doi:10.1172/JCI16956 [
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Figure 3Immunofluorescent detection of αENaC in kidney cortex of
Scnn1aloxlox and
Scnn1aloxloxCre mice kept on a sodium-free diet for 6 days. In mice of both genotypes, αENaC is highly abundant in CNT profiles grouped around cortical radial arteries and veins located in the cortical labyrinth. Late DCT profiles exhibit a weak immunostaining. CDs running in the medullary rays are stained in
loxlox (control) mice but are unstained in
loxloxCre (experimental) mice. A, arteries; V, veins; CL, cortical labyrinth; MR, medullary rays; P, proximal tubules. Scale bar, 50 μm.
