Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance
J. Clin. Invest. Isabelle Rubera, et al. 112:554 doi:10.1172/JCI16956 [Go to this article.]

Figure 1
Expression of the Hoxb7 promoter using the CreRosa 26 reporter system. The activity of Hoxb7-Cre is assayed by analysis of the Rosa reporter. (a) An intact P1 kidney stained with X-gal showing that Hoxb7-Cre is active in the CCDs and ureter (magnification, ×20). (b) A stained, thick section reveals Hoxb7-Cre activity throughout the CCD and MCD system (magnification, ×50). (c) 20 μM sections of stained kidneys demonstrate that Hoxb7-Cre is active in most if not all cells of the CD system (magnification, ×400). Some additional, mosaic staining is viewed in cells of the CNT and/or DCT, most likely due to mixing of cells at the fusion point of these two lineages.