Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720
J. Clin. Invest. Yong-Mi Kim, et al. 111:659 doi:10.1172/JCI16950 [
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Figure 3FTY reduces GvHD-associated tissue infiltration. Large-bowel tissues are shown (×50) from one representative animal in each group. Lethally irradiated B6D2F1 mice (9.75 Gy) were reconstituted with either syngeneic BMCs (5 × 10
6) and spleen cells (1 × 10
6) for hematopoietic rescue (
n = 2), or an inoculum of haplotype-mismatched GvHD-inducing allogeneic BMCs (5 × 10
6) and spleen cells (1 × 10
6) from C3D2F1 mice with (
n = 7) or without (
n = 7) 3 mg/kg/d FTY (days 0–11 or 0–13). Tissues are from representative animals of the syngeneic control group (
a), the untreated allogeneic group (
b), and the FTY-treated allogeneic group (
c) that were sacrificed on day 13 post-BMT.
