Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720
J. Clin. Invest. Yong-Mi Kim, et al. 111:659 doi:10.1172/JCI16950 [
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Figure 1FTY decreases GvHD mortality and inhibits GvHD-associated weight loss. (
a) GvHD mortality. (
b and
c) Weight curves of the syngeneic groups (
b) and allogeneic groups (
c). Lethally irradiated B6D2F1 mice received haplotype-mismatched GvHD-inducing C3D2F1 BMCs (5 × 10
6) and spleen cells (1 × 10
6), as well as daily treatment, by oral gavage on days 0–29 post-BMT, with either H
2O (filled inverted triangles;
n = 10) or FTY at a dose of 3 mg/kg (filled circles;
n = 10), 1 mg/kg (filled squares;
n = 10), or 0.1 mg/kg (filled diamonds;
n = 10). Syngeneic control groups received 5 × 10
6 B6D2F1 BMCs and either H
2O (open inverted triangles;
n = 5) or different doses of FTY (3 mg/kg, open circles,
n = 5; 1 mg/kg, open squares,
n = 5; or 0.1 mg/kg, open diamonds,
n = 5). *Statistically significant difference compared with H
2O-treated control group (
P < 0.05).
