A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation
J. Clin. Invest. Prakash C. Viswanathan, et al. 111:341 doi:10.1172/JCI16879 [
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Figure 4Recovery from inactivation. (
a) Recovery was evaluated using the two-pulse protocol shown in the inset. Data points were fitted using a two-exponential function with the fast time constant corresponding to recovery from fast inactivation and the slow time constant corresponding to recovery from slow inactivation. Plotted are the results obtained from wild type, T512I, and H558R/T512I. (
b) Development of slow inactivation of wild type and 1795
insD using the protocol shown in Figure
3b inset. It is observed that H558R had no effect in attenuating the slow inactivation caused by 1795
insD.
