A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation
J. Clin. Invest. Prakash C. Viswanathan, et al. 111:341 doi:10.1172/JCI16879 [Go to this article.]

Figure 3
Development of slow inactivation. (a) Slow inactivation was evaluated using the two-pulse protocol shown in the inset in b. Plot shows the ratio of P2/P1 for wild-type, T512I, and H558R/T512I as a function of duration of P1 pulse. Data points were fitted using a two-exponential function. While T512I dramatically enhanced slow inactivation, H558R attenuated slow inactivation caused by T512I alone. (b) Slow inactivation of wild type and H558R. Inset shows the protocol used for evaluation. Slow inactivation of H558R was not different from wild type.