IL-12 is required for differentiation of pathogenic CD8⁺ T cell effectors that cause myocarditis
J. Clin. Invest. Nir Grabie, et al. 111:671 doi:10.1172/JCI16867 [Go to this article.]

Figure 4
Cardiac IFN-γ mRNA expression and serum troponin T levels in CMy-mOva mice. (a) Total RNA was isolated from hearts removed from untreated CMy-mOva mice (labeled None) or from hearts removed 72 hours after adoptive transfer of 2.5 × 10⁶ OT-I effectors, as indicated. Real-time RT-PCR quantification of IFN-γ mRNA was performed. Data represent means ± SD (n = 4 mice per group). (b) Troponin T was measured by ELISA in serum samples collected from CMy-mOva mice 72 hours after adoptive transfer of 2.5 × 10⁶ OT-I effector cells. Data represent means ± SD (n = 4 mice per group).