IL-12 is required for differentiation of pathogenic CD8⁺ T cell effectors that cause myocarditis
J. Clin. Invest. Nir Grabie, et al. 111:671 doi:10.1172/JCI16867 [Go to this article.]

Figure 1
CMy-mOva transgene construct and expression. (a) A map of the transgene construct used in the CMy-mOva line is shown. The Ova_258–265 and Ova_323–339 epitopes are recognized by OT-I and OT-II TCR transgenic T cells, respectively. BGHpA, bovine growth hormone polyadenylation signal; TM, transmembrane domain; frag, DNA fragment. (b) Real-time RT-PCR analysis of transgenic mOva RNA expression in various tissues of CMy-mOva mice. L.N., lymph nodes; S.C.L.N., subcutaneous lymph nodes.