Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
J. Clin. Invest. David Q.-H. Wang, et al. 114:521 doi:10.1172/JCI16801 [Go to this article.]

Figure 3
Percentage cholesterol absorption, as determined by the plasma dual-isotope ratio method (27, 30, 31) in chow-fed WT and CCK-1R^–/– mice (n = 14 per group). The CCK-1R^–/– mice displayed significantly (P < 0.01) higher intestinal cholesterol absorption efficiencies compared with the WT mice (see details in Methods and Discussion). Because of dilution of radioisotopic cholesterol by the high-cholesterol diet, this method cannot be used to study percentage cholesterol absorption when mice are fed the lithogenic (gallstone-inducing) diet. However, as shown in Table 2, cholesterol mass balance studies are used under these conditions.