Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
J. Clin. Invest. David Q.-H. Wang, et al. 114:521 doi:10.1172/JCI16801 [Go to this article.]

Figure 2
Total biliary lipid outputs (μmol/h/kg BW) during the first hour of interruption of the enterohepatic circulation in WT and CCK-1R^–/– mice (n = 6 per group) after feeding the lithogenic diet for 12 weeks. (A) The CCK-1R^–/– mice displayed significantly higher biliary cholesterol outputs (P < 0.05) compared with the WT mice. However, biliary outputs of (B) lecithin and (C) bile salts were similar between the two sets of mice.