Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
J. Clin. Invest. Hiroaki Yagyu, et al. 111:419 doi:10.1172/JCI16751 [
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Figure 5Evidence for cardiomyopathy. (
a) Heart size. Hearts were obtained from 4-month-old male mice, and the heart weight was divided by total body weight. The hLpL
GPI/
LpL1 mice (filled circles,
n = 11) had larger hearts (milligrams per gram body weight) than
LpL1 mice (open circles,
n = 11). *
P < 0.02. (
b and
c) Survival. Breeding female hLpL
GPI/
LpL1 mice (
n = 11) died more frequently than
LpL1 female mice (
n = 14); males also died more rapidly. The hLpL
GPI/
LpL1 males (
n = 8) also died more rapidly than
LpL1 male mice (
n = 14). Differences among survival curves were compared using Kaplan-Meier survival analysis. *
P < 0.01.
