Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
J. Clin. Invest. Hiroaki Yagyu, et al. 111:419 doi:10.1172/JCI16751 [Go to this article.]

Figure 1
The hLpL^GPI DNA construction. (a) The human LpL minigene with a muscle creatine kinase promoter was used as a template DNA for generating the hLpL^GPI DNA construction. The translational start codon (ATG), stop codon (TGA), and the polyadenylation signal (PolyA) are indicated. MCK, muscle creatine kinase. (b) The hLpL^GPI DNA was inserted into the plasmid containing the CMV promoter for expression in transfected cells. (c) The hLpL^GPI DNA was subcloned into the plasmid containing the α-MHC promoter. The probe used for Northern blot analysis is indicated. kbps, kilobasepairs.