Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation
J. Clin. Invest. David Philippe, et al. 111:1329 doi:10.1172/JCI16750 [
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Figure 3DALDA improves the histologic lesions and decreases the MPO level induced by TNBS. (
a–
c) Histologic examination of colon sections of mice receiving vehicle only, TNBS, or 10
–2 mg/kg/d DALDA followed 4 days later by TNBS (DALDA + TNBS) (magnification, ×250). TNBS induced severe lesions characterized by an intense inflammatory infiltrate extending deep into the colon wall with necrosis (
b). Treatment with DALDA reduced the intensity of histologic inflammation, which was characterized only by a moderate inflammatory infiltrate located in the mucosa (
c). (
d) The histologic anti-inflammatory effects of DALDA (10
–2 mg/kg/d) were assessed preventively 2 days and 4 days after TNBS administration. Colon MPO levels were evaluated 4 days after colitis induction. Severity of lesions was evaluated using the histologic scoring method of Ameho. The number of mice and statistical significance are indicated and results are expressed as mean ± SEM.
