Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation
J. Clin. Invest. David Philippe, et al. 111:1329 doi:10.1172/JCI16750 [
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Figure 2DALDA improves the macroscopic lesions induced by TNBS. (
a) Morphologic examination of mice receiving vehicle only (control), TNBS, or DALDA (10
–2 mg/kg/d) 4 days prior to the administration of TNBS (DALDA + TNBS). (
b) The anti-inflammatory effects of DALDA (10
–2 mg/kg/d) were assessed preventively 2 days (day 2) and 4 days (day 4) after TNBS administration. Severity of lesions was evaluated using the macroscopic Wallace score. The number of mice and statistical significance are indicated and results are expressed as mean ± SEM.
