Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice
J. Clin. Invest. Julia I. Leu, et al. 111:129 doi:10.1172/JCI16712 [Go to this article.]

Figure 2
Increased caspase-8 and caspase-3 activation in IGFBP-1^–/– livers after Fas mAb injection. (a–d) Immunohistologic staining of IGFBP-1^–/– liver sections at time 0 (a) and 3 hours (c), and IGFBP-1^+/+ liver sections at 1 hour (b) and 3 hours (d) after Fas challenge using anti–caspase-8 p10 Ab. (e and f) Immunohistologic staining of IGFBP-1^–/– liver section at 3 hours (e) and IGFBP-1^+/+ liver section at 3 hours (f) using anti–caspase-3 p17 Ab. Scale bars: 10 μm (a–d) and 50 μm (e and f).